Severe Malaria Complicated by G6PD Deficiency in a Pediatric Tanzanian Immigrant
نویسندگان
چکیده
منابع مشابه
Polymorphism analysis of malaria susceptibility biomarkers in G6PD deficiency patients
Abstract Background: Several studies suggested that some traits and polymorphisms in human genome such as G6PD deficiency and other genes have protective effects on susceptibility to malaria infection . Methods: In present study we investigated the prevalence of TNF [1] -244GgA, TNF [1] - 308 GgA,TNF [1] -238GgA, NOS2-954GgC, MBL54GgA, MBL 57GgA, MBL IVSI - 5 GgA polymorphisms and G6P...
متن کاملSevere malaria in immigrant haematological patient
Severe malaria is a life-threatening condition caused by Plasmodium falciparum. Rupture of red blood cells when merozoites release to the bloodstream is responsible for the clinical manifestations, febrile fever reaching 39 °C, and other unspecific symptoms. P. falciparum is considered as the worst form of malaria. Moreover, this species has cytoadherence to red blood cells. This can lead to an...
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BACKGROUND Although a substantial decline of Plasmodium falciparum infection is observed in Africa following implementation of new control strategies, malaria is still considered as the major cause of febrile illness in hospitalized African children. The present study was designed to assess the management of febrile illness and to determine the proportion of children with febrile illness hospit...
متن کاملCharacterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is believed to confer protection against Plasmodium falciparum malaria, but the precise nature of the protective effecthas proved difficult to define as G6PD deficiency has multiple allelic variants with different effects in males and females, and it has heterogeneous effects on the clinical outcome of P. falciparum infection. Here we report a...
متن کاملX-Linked G6PD Deficiency Protects Hemizygous Males but Not Heterozygous Females against Severe Malaria
BACKGROUND Glucose-6-phosphate dehydrogenase (G6PD) is important in the control of oxidant stress in erythrocytes, the host cells for Plasmodium falciparum. Mutations in this enzyme produce X-linked deficiency states associated with protection against malaria, notably in Africa where the A- form of G6PD deficiency is widespread. Some reports have proposed that heterozygous females with mosaic p...
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ژورنال
عنوان ژورنال: The Journal of Pediatric Pharmacology and Therapeutics
سال: 2014
ISSN: 1551-6776
DOI: 10.5863/1551-6776-19.4.325